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. 2013 Jan 24;8(1):e53752. doi: 10.1371/journal.pone.0053752

Figure 7. hScrib suppresses HPV-16 E7 and EJ-ras induced transformation in cooperation with PP1γ in a RVxF motif-dependent manner.

Figure 7

BRK cells were transfected with EJ-ras alone, HPV-16 E7 plus EJ-ras, HPV-16 E7 plus EJ-ras and wild type hScrib, HPV-16 E7 plus EJ-ras and PP1γ, and HPV-16 E7 plus EJ-ras and wild type hScrib with PP1γ, and HPV-16 E7 plus EJ-ras and PP1γ plus the KADA non-PP1γ binding mutant of hScrib. After three weeks the dishes were fixed and stained and the colonies counted. Results represent the mean number of colonies from 3 independent assays and standard deviations are shown.