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. 2013 Jan 24;8(1):e54590. doi: 10.1371/journal.pone.0054590

Figure 4. Progesterone reduced the increase of GFAP-positive cells in the corpus callosum and increased PDGFRα-positive OPCs.

Figure 4

GFAP-positive cells were observed in the N+Veh group (A), N+P group (B), CPZ+Veh group (C), and CPZ+P group (D) in the corpus callosum of mice. (I) Statistical analyses showed that GFAP-positive cells decreased in the CPZ+P group compared with the CPZ+Veh group. Bar = 50 µm. *CPZ+P vs. CPZ+Veh group, P<0.05; **CPZ+Veh vs. N+Veh group, P<0.01. PDGFRα-positive OPCs were observed in the SVZ of mice in the N+Veh group (E and E’), N+P group (F), CPZ+Veh group (G), and CPZ+P group (H). (J) Statistical analyses showed that PDGFRα-positive cells increased in the CPZ+P group compared with the CPZ+Veh group. The number of PDGFRα-positive OPCs per mm2 is seen in the corpus callosum (K). Bar = 50 µm in A–H; Bar = 10 µm in E’. **CPZ+Veh vs. N+Veh group; CPZ+P vs. CPZ+Veh group, P<0.01.