Table 1. The most significantly differentially expressed miRNAs in HepG2/DOX cells.
| miRNA ID | log2(fold change)* | Up/down expression | P- value adjusted | miRNA ID | log2(fold change)* | Up/down expression | P- value adjusted |
| hsa-miR-181a-3p | 9.04 | Up | 1.56E-23 | hsa-miR-338-3p | −11.63 | Down | 4.47E-133 |
| hsa-miR-3660 | 7.87 | Up | 1.95E-11 | hsa-miR-486-3p | −8.90 | Down | 2.14E-21 |
| hsa-miR-2682-5p | 7.77 | Up | 7.78E-11 | hsa-miR-944 | −8.39 | Down | 1.61E-15 |
| hsa-miR-551b-3p | 7.39 | Up | 9.63E-09 | hsa-miR-2277-5p | −8.01 | Down | 2.67E-12 |
| hsa-miR-3117-3p | 7.26 | Up | 3.73E-08 | hsa-miR-338-5p | −8.01 | Down | 2.68E-12 |
| hsa-miR-551b-5p | 7.11 | Up | 1.49E-07 | hsa-miR-139-3p | −7.96 | Down | 9.21E-75 |
| hsa-miR-548h-5p | 6.95 | Up | 5.93E-07 | hsa-miR-4427 | −7.36 | Down | 1.58E-08 |
| hsa-miR-296-3p | 6.60 | Up | 8.05E-29 | hsa-miR-3186-3p | −7.01 | Down | 4.40E-07 |
| hsa-miR-4488 | 5.95 | Up | 4.10E-35 | hsa-miR-1269b | −6.74 | Down | 3.15E-06 |
| hsa-miR-296-5p | 5.84 | Up | 3.88E-78 | hsa-miR-3674 | −6.74 | Down | 3.16E-06 |
| hsa-miR-4454 | 5.19 | Up | 3.07E-85 | hsa-miR-3910 | −6.74 | Down | 3.17E-06 |
| hsa-miR-4687-3p | 4.37 | Up | 8.32E-26 | hsa-miR-642a-3p | −6.74 | Down | 5.10E-32 |
| hsa-miR-3654 | 3.38 | Up | 1.21E-25 | hsa-miR-486-5p | −6.46 | Down | 2.81E-100 |
| hsa-miR-577 | 2.94 | Up | 8.64E-05 | hsa-miR-203 | −6.30 | Down | 3.19E-89 |
| hsa-miR-4508 | 2.9 | Up | 5.94E-06 | hsa-miR-1277-3p | −6.16 | Down | 3.01E-41 |
| hsa-miR-3687 | 2.49 | Up | 2.04E-05 | hsa-miR-1277-5p | −5.90 | Down | 3.84E-18 |
| hsa-miR-4448 | 2.45 | Up | 1.66E-04 | hsa-miR-1250 | −5.71 | Down | 2.05E-169 |
| hsa-miR-4426 | 2.23 | Up | 3.53E-05 | hsa-miR-139-5p | −5.46 | Down | 3.71E-25 |
| hsa-miR-720 | 2.08 | Up | 1.21E-05 | hsa-miR-335-5p | −5.26 | Down | 2.00E-41 |
| hsa-miR-4485 | 1.71 | Up | 6.14E-08 | hsa-miR-362-3p | −5.01 | Down | 3.36E-10 |
| hsa-miR-877-5p | 1.68 | Up | 1.92E-82 | hsa-miR-1255a | −4.92 | Down | 1.25E-62 |
| hsa-miR-3679-5p | 1.45 | Up | 5.53E-04 | hsa-miR-3622a-5p | −4.83 | Down | 4.30E-09 |
| hsa-miR-21-3p | 1.40 | Up | 7.87E-13 | hsa-miR-1293 | −4.67 | Down | 2.87E-08 |
| hsa-miR-2116-3p | −4.64 | Down | 3.67E-14 | ||||
| hsa-miR-365a-3p | −4.52 | Down | 8.20E-62 | ||||
| hsa-miR-365b-3p | −4.52 | Down | 8.29E-62 | ||||
| hsa-miR-4501 | −4.22 | Down | 2.27E-06 | ||||
| hsa-miR-196a-3p | −4.14 | Down | 4.15E-06 | ||||
| hsa-miR-500a-5p | −4.01 | Down | 2.94E-09 | ||||
| hsa-miR-500b | −4.01 | Down | 2.94E-09 |
Note: *fold change = (HepG2/DOX)/HepG2.