Table 2. Invasive pneumococcal disease due to PCV7 serotypes in PCV7 vaccinated children, Denmark 2007–2010 (n = 10).

Sex	No. of PCV7 doses received before IPD	No. of days between last PCV7 dose and IPD	Clinical presentation at admission	Comorbid Conditions	Vital status	Vaccine failure (Yes/No)*
M	1	7	Sepsis	None known	alive	No
F	2	516	Bacteremia	Complement (C2) deficiency (homozygote), MBL deficiency	alive	No
F	3	536	Bacteremia, febrile leucopenia	Acute myeloid leukaemia	alive	Yes
F	1	20	Meningitis, sepsis	None known	alive	No
M	1	145	Sepsis	Acute myeloblastic leukaemia	alive	No
F	2	207	Acute otitis media, bacteremia	None known	alive	Yes
F	1	10	Arthritis	None known	alive	No
M	1	43	Sepsis, possibly otogenic focus	None known	alive	No
M	2	71	Meningitis	None known	alive	Yes
M	1	263	Bacteremic pneumonia	Multi-handicapped child	alive	No

A case of vaccine failure is defined as a child with IPD caused by any of the serotypes included in all the vaccine doses the child has received, and where one of the three following criteria are met: 1) the child is under 13 months of age at IPD onset and has received 2 doses of PCV7/PCV13 but not yet the booster dose and becomes ill more than 2 weeks after the last dose was given; 2) the child is at least 12 months old at IPD onset, completed primary vaccination before 12 months of age and becomes ill more than 1 week after administration of the booster dose 3) the child is at least 6 months old at IPD onset, received 2 doses of PCV7 as a part of the catch-up program and becomes ill more than 2 weeks after the administration of the last dose. Vital status was recorded at 30 days after IPD. None of the patients presenting IPD due to PCV7 or one of the 6 additional serotypes in PCV13 were vaccinated with PCV13.