Figure 4. Number of kinetic parameter vectors (vertical axis) that lead to large Gradient (Gradient>400) for MAPK activation (see text).

As in Figure 3, the numbers are shown for different ratios (horizontal axis) of (a) various association rates (kbN and kb-N) over the respective dissociation rates (kdN and kd-N), and (b) various activation rates (kN) over the respective deactivation rate (k-N).