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. 2013 Jan 21;19(3):339–346. doi: 10.3748/wjg.v19.i3.339

Table 3.

Sensitivity of α-fetoprotein-L3 and prothrombin induced by vitamin K absence-II according to the tumor characteristics in 38 hepatocellular carcinoma patients with α-fetoprotein < 20 ng/mL n (%)

n AFP-L3 PIVKA-II AFP-L3 and PIVKA-II combined
(> 5%) (> 40 AU/L) (> 5%, > 40 AU/L)
Tumor stage (UICC)
I 11 7 (63.6) 5 (45.5) 9 (81.8)
II 16 12 (75.0) 9 (56.3) 16 (100)
III 9 6 (66.7) 6 (66.7) 8 (88.9)
IVa 2 2 (100) 2 (100) 2 (100)
Tumor size
< 2 cm 15 7 (46.7) 6 (40.0) 13 (86.7)
2-5 cm 17 8 (47.1) 11 (64.7) 16 (94.1)
> 5 cm 6 3 (50.0) 5 (83.3) 6 (100)
Tumor number
Single 24 16 (66.7) 12 (50.0) 22 (91.7)
Multiple 14 11 (78.6) 10 (71.4) 13 (92.7)

AFP: α-fetoprotein; PIVKA-II: Prothrombin induced by vitamin K absence-II; UICC: International Union Against Cancer; HCC: Hepatocellular carcinoma.