Skip to main content
. Author manuscript; available in PMC: 2014 Jul 1.
Published in final edited form as: Brain Behav Immun. 2012 Aug 19;31:134–142. doi: 10.1016/j.bbi.2012.08.008

Figure 4. LPS-induced increase in the ratios of 5-HIAA to 5-HT and 3-HK to TRP in the brain were reduced by 1-MT.

Figure 4

CX3CR1−/− mice were implanted s.c. with either placebo or 1-MT filled pellets three days prior to i.p. injection of saline or LPS (0.5mg/kg). Brains were collected and TRP and several other TRP-related metabolites were determined 72 h later. A) 5-HIAA:5-HT and B) 3-HK:TRP ratios are shown. Bars represent the mean ± SEM. Means with different letters (a or b) are significantly different (p < 0.05) from each other.