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. Author manuscript; available in PMC: 2014 Jan 1.
Published in final edited form as: J Am Soc Mass Spectrom. 2012 Dec 4;24(1):30–37. doi: 10.1007/s13361-012-0506-8

Figure 2.

Figure 2

The covalent chemistry described requires both a carboxylic acid and a carbodiimide to occur. (a) An ion/ion reaction between a PAMAM G0.5 sodium salt analyte and CMC produces an ion/ion complex. (b) However, CID of the complex does not result in a signature loss of 125 Da. (c) Similarly, oxidation of the carbodiimide functionality to a urea functionality renders the carbodiimide reagent (now CMU, structure inset) unreactive towards the original PAMAM G0.5 dendrimer.