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. 1974 Jul;14(1):133–138. doi: 10.1128/jvi.14.1.133-138.1974

Baboon Virus Isolate M-7 with Properties Similar to Feline Virus RD-114

Alfred Hellman 1,2,3, Paul T Peebles 1,2,3, James E Strickland 1,2,3, Arnold K Fowler 1,2,3, S S Kalter 1,2,3, S Oroszlan 1,2,3, R V Gilden 1,2,3
PMCID: PMC355486  PMID: 4134740

Abstract

A virus (M-7) isolated from baboon placental tissue demonstrates many similarities to endogenous feline virus RD-114. Immunodiffusion analysis shows a group-specific antigen (gs-1) line of identity between M-7 and RD-114. Anti-RD-114 DNA polymerase IgG inhibits M-7 polymerase by 57% compared to 97% for RD-114. M-7 virus has helper activity as demonstrated by rescue of murine sarcoma virus (MSV) from sarcoma-positive leukemia-negative human amnion cells. The host range of the rescued M-7 pseudotype of MSV, MSV (M-7), is similar to that of RD-114 virus. MSV (M-7) is also able to transform baboon cells and causes no detectable transformation of feline cells without addition of helper feline leukemia virus. Interference properties of M-7 and RD-114 virus are identical. Virus-specific neutralizing antisera, although partially cross-reacting, can distinguish MSV (M-7) from MSV (RD-114). These similarities and differences between RD-114 and M-7 viruses are best explained as type-specific differences between two viruses within the same strain.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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