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. Author manuscript; available in PMC: 2014 Mar 1.
Published in final edited form as: Brain Behav Immun. 2012 Sep 28;29:1–8. doi: 10.1016/j.bbi.2012.09.008

Figure 2. Emergent and fluid modularity of biology.

Figure 2

Networks were constructed for linking N=37 markers of immune and neuroendocrine status in patients with chronic fatigue syndrome (CFS) and in healthy control subjects. Inferring coherent modules on the basis of network topology (network modularity M) (Broderick et al., 2010), cohesive modules were found that formed coarse networks of N=13 and N=5 aggregate nodes in CFS. In contrast only one coarse network of N=8 aggregate nodes was found in healthy controls. This aligned with a top-down aggregation of N=10 organ-specific nodes based on known anatomical annotation (Fuite, Vernon and Broderick, 2008a, b).