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HGF-induced Rac1 activation involves ITGB4-mediated signaling. A, HPAEC were transfected with nonspecific (ns) siRNA or ITGB4 siRNA prior to treatment with HGF (25 ng/ml, 5 min). Cell lysates were then prepared and analyzed for Rac1 activation (GTP-Rac1). Representative blots are shown. B, densitometry analysis of Rac1 activation is expressed as a percentage relative to control cells (ns siRNA, untreated) (n = 3/group, *, p < 0.05).
