FIGURE 1.
499-prestin is a functional motor. A and B, effect of pentanesulfonate on WT (A) and 499ki OHCs (B). NLC was measured in the presence (gray) or absence (black) of pentanesulfonate. C and D, motor function of WT (C) and 499ki OHCs (D) measured in the presence of iodide. Five representative results of OHC displacement are shown together with a representative NLC (inset). Typical voltage-dependent OHC displacement and bell-shaped NLC of 499ki became evident due to the hyperpolarizing Vpk shift induced by iodide. The motility responses were analyzed using Equation 2 (solid lines).