FIGURE 7.

Electromechanical coupling efficiencies of WT, 499het, and 499ki OHCs determined for the 391/781-Hz stimulus. OHC displacements and associated NLC were measured under iodide and chloride conditions, and the resulting electromechanical coupling efficiencies were plotted in A and B, respectively. See Fig. 1 for representative recordings of WT and 499ki OHCs under iodide condition and Fig. 6 and supplemental Fig. S4 for WT and 499het OHCs under the chloride condition. The d/q values are 1.4 ± 0.4 nm/fC (average ± S.D., n = 15) for WT OHCs and 4.4 ± 1.4 nm/fC (average ± S.D., n = 11) for 499ki OHCs (p < 0.0001) under the iodide condition (A) and 2.0 ± 0.6 nm/fC (average ± S.D., n = 11) for WT OHCs and 3.3 ± 1.1 nm/fC (average ± S.D., n = 10) for 499het OHCs (p = 0.0014) under the chloride condition (B). Error bars represent S.D.