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Effect of imatinib in vivo. Rats were administered with saline or imatinib (30 mg/kg) twice daily for 5 days or vehicle and a GSI (10 mg/kg) for 4 h. Plasma (a and c) or brain extracts (b and d) were assayed for Aβ40 using a sensitive immunoassay. Statistical analysis was conducted using a one-way ANOVA with Dunnett's multiple comparison test (***, p < 0.0001).
