FIGURE 11.

Cell proliferation in the SVZ is increased after mating in control but not ERK5 icKO mice. Two weeks after a 7-day tamoxifen administration, female mice were mated with male mice and BrdU incorporation was examined at GD7. Virgin littermates that were not paired with males were used as controls. A–D, confocal images of BrdU staining in the SVZ of virgin (A, C) or mated (B, D) mice that are either of control (A, B) or ERK5 icKO (C, D). Scale bar: 50 μm. E, quantification of the total number of BrdU⁺ cells in the SVZ of control and ERK5 icKO mice. n = 4/genotype/treatment. **, p < 0.01; n.s. not statistically significant.