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. 2013 Feb 1;111(3):400–405. doi: 10.1016/j.amjcard.2012.10.017

Figure 1.

Figure 1

DES variants identified in patients with ARVC. (Top) Sequence electropherograms showing p.A213V and p.K241E amino acid substitutions and intronic nucleotide change c.736-11A>G detected in DES gene. (Bottom) ClustalW (European Molecular Biology Laboratory–European Bioinformatics Institute, Cambridgeshire, United Kingdom) alignment showing evolutionary conservation of highly conserved 1B desmin subdomain among species. Organism names and Genbank Accession numbers are reported on the sides (Cf = Canis familiaris; Dr = Danio rerio; Gg = Gallus gallus; Hs = Homo sapiens; Mm = Mus musculus; Rn = Rattus norvegicus; Ss = Sus scrofa; Xl = Xenopus laevis).