(A) Mean plasma concentration of S1RA over a 24 h period after single oral doses of 5–800 mg (linear scale). (B) Mean plasma concentration of S1RA over time after single oral doses of 5–800 mg (logarithmic scale). Study 101: , 5 mg; , 10 mg; , 20 mg; , 40 mg; , 60 mg; , 100 mg; , 140 mg; , 200 mg; , 300 mg; , 400 mg; , 500 mg. Study 106: , 500 mg; , 600 mg; , 800 mg