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. 2012 May 23;75(1):136–145. doi: 10.1111/j.1365-2125.2012.04339.x

Figure 5.

Figure 5

Plots of mean % (with 95% CI) of BL of exploratory biomarkers of Notch toxicity: (A) BIRC3, (B) DUSP6, (C) HES1 and (D) TFF3 vs. time for the healthy male group (aged 46–59 years) and two elderly groups (aged 60–74 years and 75 years or more). AD, Alzheimer's disease; BIRC3, baculoviral IAP repeat-containing protein 3; DUSP6, dual specificity phosphatase 6; HES1, hair and enhancer of split 1; MCI, mild cognitive impairment; TFF3, trefoil factor 3. Inline graphic light line placebo; Inline graphic dark line active