Table 2.
Summary statistics of PK parameters for avagacestat (50 mg in capsule formulation)
| Age group (years) | Cmax, ng ml−1 GM (% CV) | AUC(0,∞) ng ml−1 h GM (% CV) | tmax, h median (min, max) | t1/2, h mean (SD) |
|---|---|---|---|---|
| 18–45, (n= 6) | 149 (43) | 1202 (41) | 1.5 (1.0, 2.0) | 41.5 (10.9) |
| 46–59, (n= 6) | 251 (27) | 1693 (27) | 1.0 (1.0, 2.1) | 44.7 (11.6) |
| 60–74, (n= 6) | 175 (19) | 1701 (28) | 1.5 (1.0, 2.1) | 46.0 (14.3) |
| ≥75, (n= 9) | 224 (34) | 2688 (40) | 1.5 (1.0, 2.0) | 70.7 (19.5) |
AUC(0,∞), area under the concentration curve from time 0 extrapolated to infinite time; CV, coefficient of variation; Cmax, maximum observed concentration; GM, geometric mean; SD, standard deviation; tmax, time of maximum observed plasma concentration; t1/2, elimination half-life.