Figure 4.

Model-based simulated concentration–time profiles of propylene glycol for three neonates (birth weight 630 g, 1500 g and 3500 g) after administration of paracetamol (800 mg propylene glycol/1000 mg paracetamol, upper panel) and phenobarbital (700 mg propylene glycol/200 mg phenobarbital, lower panel) in doses according to Table 3. The grey lines illustrate the concentration–time profiles for the neonates at birth. The black lines represent the concentration–time profiles at a postnatal age of 28 days (current weight 950 g, 1950 g and 4100 g)