. 2012 May 11;75(1):172–179. doi: 10.1111/j.1365-2125.2012.04324.x

Table 1.

Pharmacokinetic variables of a single 50 mg dose of atenolol in 12 healthy volunteers during the water, 1200 ml apple juice and 600 ml apple juice phases

					Geometric mean ratio
	Water	Apple juice (1200 ml)	Apple juice (600 ml)	Apple juice 1200 ml/water	Apple juice 600 ml/water	Apple juice 1200 ml/apple juice 600 ml
Total (n=12)
t_max (h)	2.50 [1.00–4.00]	1.50 [1.00–2.00]	2.00 [1.00–6.00]	–	–	–
C_max (ng ml⁻¹)	216 (183, 254)	44.3 (37.6, 52.2)	68.0 (56.7, 81.5)	0.21 (0.17, 0.25)^**	0.32 (0.26, 0.38)^**	0.65 (0.54, 0.79)^**
AUC(0,t_last) (ng ml⁻¹ h)	2,110 (1,635, 2,723)	389.7 (302.0, 503.0)	885.3 (662.6, 1183)	0.18 (0.13, 0.25)^**	0.42 (0.30, 0.59)^**	0.44 (0.31, 0.62)^**
t_1/2 (h)	9.93 (7.33, 13.5)	10.5 (7.73, 14.2)	12.8 (9.14, 17.9)	–	–	–
SLCO2B1^1/^1 (n=6)
t_max (h)	2.50 [1.00–4.00]	1.50 [1.00–2.00]	2.00 [1.00–4.00]	–	–	–
C_max (ng ml⁻¹)	228 (168, 310)	44.9 (33.1, 61.1)	64.2 (46.7, 88.3)	0.20 (0.15, 0.26)^**	0.28 (0.21, 0.38)^**	0.70 (0.52, 0.94)^*
AUC(0,t_last) (ng ml⁻¹ h)	2,182 (1,568, 3,036)	359.0 (258.0, 499.4)	902.9 (633.7, 1,287)	0.16 (0.11, 0.24)^**	0.41 (0.27, 0.63)^*	0.40 (0.26, 0.60)^**
t_1/2 (h)	9.64 (6.66, 13.9)	9.48 (6.55, 13.7)	11.6 (7.76, 17.3)	–	–	–
SLCO2B1^3/^3 (n=6)
t_max (h)	2.50 [1.50-4.00]	1.50 [1.00–2.00]	2.25 [1.50-6.00]	–	–	–
C_max (ng ml⁻¹)	204 (168, 247)	43.6 (36.0, 52.9)	75.2 (59.4, 95.2)	0.21 (0.16, 0.29)^**	0.37 (0.27, 0.51)^**	0.58 (0.42, 0.79)^*
AUC(0,t_last) (ng ml⁻¹ h)	2,040 (1,284, 3,241)	423.1 (266.2, 672.2)	859.1 (493.3, 1496)	0.21 (0.11, 0.38)^**	0.42 (0.21, 0.83)^*	0.49 (0.25, 0.97)^*
t_1/2 (h)	10.2 (5.78, 18.1)	11.5 (6.52, 20.4)	14.1 (7.43, 26.7)	–	–	–

The data are presented as the geometric mean (95% confidence interval) except for t_max, which is given as the median [minimum-maximum].

Apple juice 600 ml: In total, nine subjects completed the study. (SLCO2B1^*1/^*1 (n= 5), SLCO2B1^*3/^*3 (n= 4)).

P < 0.05.

^**

P < 0.001.