Table 2.

CL_cr, CL weight⁻¹, V weight⁻¹ and AUC broken down for ciprofloxacin 24 h dose categories and age group

		CLcr (ml min−1)	CL weight−1 (l h−1 kg−1)	V weight−1 (l kg−1)	AUC (mg l−1 h)
		Median (range)	Median (range)	Median (range)	Median (range)
	n	Mean (SD)	Mean (SD)	Mean (SD)	Mean (SD)
24 h dose (mg)
400–600	24	24 (8–184)	0.15 (0.06–0.45)	2.4 (0.9–4.4)	39 (15–78)
		39 (43)	0.17 (0.09)	2.3 (0.8)	41 (16)
800	51	81 (12–162)	0.25 (0.04–0.51)	2.5 (1.2–5.9)	45 (23–128)
		81 (39)	0.26 (0.11)	2.6 (1.0)	52 (25)
1200	5	131 (37–173)	0.52 (0.12–0.57)	2.7 (1.3–4.4)	44 (29–89)
		113 (52)	0.39 (0.21)	2.9 (1.2)	53 (27)
Age group (years)
<70	41	79 (12–184)	0.27 (0.07–0.57)	2.1 (1.3–4.4)	38 (15–125)
		85 (49)	0.29 (0.13)	2.6 (0.7)	43 (20)
70–80	24	55 (8–131)	0.20 (0.04–0.45)	2.4 (1.0–6.0)	47 (23–96)
		58 (40)	0.21 (0.11)	2.4 (1.2)	52 (22)
>80	15	37 (12–119)	0.13 (0.06–0.37)	2.4 (0.9–5.7)	63 (24–128)
		51 (33)	0.16 (0.09)	2.3 (1.1)	59 (27)

CL_cr, creatinine clearance; CL weight⁻¹, ciprofloxacin clearance corrected for bodyweight; V weight⁻¹, volume of distribution corrected for bodyweight; AUC, area under the curve in 24 h.