Table 1.

Pharmacological strategies for targeting GBM-SCs.

Strategy	Targets	Reference
Canonical pathway inhibitors	EGFR, TGF-β, c-MET, PI3K/Akt, STAT3	Eyler et al. (2008), Bleau et al. (2009), Sherry et al. (2009), Anido et al. (2010), Jin et al. (2011), Joo et al. (2012)
Self-renewal pathway inhibitors	Sonic Hedgehog, Notch	Bar et al. (2007), Fan et al. (2010)
Differentiation-inducing agents	Retinoic acid, BMPs, IFN-β	Piccirillo et al. (2006), Yuki et al. (2009), Ying et al. (2011), Tate et al. (2012)
CSC-microenvironment disrupting agents	HIFs, VEGF/VEGFR axis, Notch	Li et al. (2009), Zhu et al. (2011), Hamerlik et al. (2012)
DNA damage response	Chk1 and Chk2	Bao et al. (2006b), Ropolo et al. (2009)