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. 2012 Sep 26;24(1):48–57. doi: 10.1089/hum.2012.039

FIG. 2.

FIG. 2.

AAV2/9-CC10 vector virus enhanced CC10 level and suppressed airway hyperresponsiveness in OVA-sensitized mice. (A) Brief protocol for OVA sensitization and AAV2/9 vector virus treatment. Mice were sensitized with OVA and treated with AAV2/9 vector virus as described in Materials and Methods. IP, intraperitoneal; IT, intratracheal injection. (B) The level of CC10 in lung tissue was determined by real-time PCR. Data are normalized to normal control mice (n=4 per group). (C) Airway hyperresponsiveness was measured by whole body plethysmography. Data are normalized to normal control mice and represented as enhanced pause (Penh) values (mean±SEM; n=6 per group). N, normal control; S, sensitized control; VC, AAV 2/9 control vector virus; CC10, AAV2/9-CC10 vector virus. *p<0.05; a**, p<0.01 vs. S; b*, p<0.05 vs. VC; b**, p<0.01 vs. VC.