FIG. 1.

Evaluation of AAV8 encoding human low-density lipoprotein receptor (LDLR) in LA-DKO mice (double knockout mice that are deficient in both Ldlr and Apobec1). (A) Plasma cholesterol levels, (B) non-HDL cholesterol, and (C) triglyceride levels were examined in LA-DKO mice after treatment with AAV8.hLDLR (n=10 animals per dose group). Each point represents the mean±SD. *p<0.05, **p<0.01. (D) Presented is the percent reduction in cholesterol as compared with baseline as a function of vector dose (GC/kg). AAV8.TBG.mLDLR is based on our previously published data (Kassim et al., 2010).