Table 2.
Plasma and Urinary Biochemistry
| Parameter | Sham (n=8) | UrineRM (n=7) | Se+ (n=9) | Se++ (n=6) |
|---|---|---|---|---|
| Na+ (10−3M) | 48.3 (29.7) | 50 (12.5) | 29.4 (20.2) | 22.8 (17.6) |
| K+ (10−3M) | 147.9 (60.9) | 137.4 (24.38) | 118.5 (21.8) | 110.7 (66.4) |
| Body weight normalized CCR (ml/min/kg) | 12.7 (2.8) | 4.3 (0.2)* | 3.6 (5.7)* | 5.5 (3.5)* |
| Protein (mg/ml) | 2.1 (1.9) | 9.5 (3.5)* | 7.8 (2.5)* | 3.0 (2.2)# |
| Protein:creatinine | 0.05 (0.04) | 0.19 (0.06)* | 0.15 (0.04)* | 0.07 (0.05)# |
| Plasma | ||||
| Na+ (10−3M) | 188.8 (52.5) | 170.7 (49.1) | 213 (45.9) | 209.3 (70.1) |
| K+ (10−3M) | 3.9 (1.2) | 4.3 (0.9) | 3.2 (0.3) | 2.6 (1.2) |
| Cl- (10−3M) | 119.4 (17.9) | 106.7 (18.8) | 103.9 (2.8) | 74.6 (46.2) |
| Urea (10−3M) | 5.3 (1.0) | 14.8 (5.2)* | 19.4 (5.6)* | 14.6 (5.9)* |
| Creatinine (10−6M) | 16.7 (12.7) | 63.3 (17.9)* | 88.6 (18.4)* | 56.2 (12.2)* |
| Ca2+ (10−3M) | 2.2 (0.4) | 2.1 (0.6) | 1.8 (0.4) | 1.4 (0.5) |
Blood plasma and urine were collected 24 h after the induction of experimental RM and concentrations of different biochemical parameters were measured. Data expressed as Mean±(SD). Units of measurement and the numbers of samples tested (n values for all parameters) are as indicated in the table. Creatinine clearance (CCR) was calculated as described in the Methods section.
*
Different to the sham group; p<0.05.
#
Different to RM and Se+ groups; p<0.05.