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. Author manuscript; available in PMC: 2013 Jan 25.
Published in final edited form as: Nature. 2012 Apr 11;485(7398):381–385. doi: 10.1038/nature11049

Figure 3. Dynamics of topologically associating domains during cell differentiation.

Figure 3

a. Comparison of 5C data from male mESCs (E14), NPCs (E14) and primary MEFs reveals general conservation of TAD positions during differentiation, but differences in their internal organisation (arrows highlight examples of tissue-specific patterns). b Lamina associated domains (LADs, from ref.19) align with TADs. Chromosomal positions of tissue-specific LADs reflect gain of lamina association by TADs, as well as internal reorganisation of lamina associated TADs during differentiation.