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Epithelial cell dissociation from morphologically normal appearing epithelial structures. A CRC tissue section from a node-positive case was double immunostained for CK AE1/3 (red) and leukocyte common antigen (LCA; brown). Circles identify epithelial structures adjacent to a small lymphatic aggregate. Thick arrows identify dissociated epithelial tumor cells and thin arrows identify associated lymphocytes. A: 100X. B: a higher magnification (400X) of A.
