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. 1974 Aug;14(2):307–314. doi: 10.1128/jvi.14.2.307-314.1974

Inhibition of Herpes Virus-Induced Cell Fusion by Concanavalin A, Antisera, and 2-Deoxy-d-Glucose

H Ludwig 1, H Becht 1, R Rott 1
PMCID: PMC355516  PMID: 4858786

Abstract

Pseudorabies virus-induced cell fusion in rabbit kidney cells can be prevented by Concanavalin A added early after infection. The infected cells are not agglutinated and the infectivity of cell-free virus is not reduced. Sera from productively infected animals also inhibit polykaryocytosis, whereas a hyperimmune serum directed against virus structural components has no effect. 2-Deoxy-d-glucose reversibly disturbs virus-induced fusion and reduces significantly the virus infectivity.

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Selected References

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