Table 4. ORs for case-control study of 10 published CRC susceptibility loci.
| SNP | Genotypes | CRC cases (n, %) | Controls (n, %) | Adjusted OR (95% CI) | P |
|---|---|---|---|---|---|
| rs12701937 | CC | 108 (48.4) | 124 (46.6) | 1.00 | |
| CT | 88 (39.5) | 111 (41.7) | 0.91 (0.62-1.34) | 0.636 | |
| TT | 27 (12.1) | 31 (11.7) | 0.98 (0.55-1.76) | 0.956 | |
| CT+TT | 115 (51.6) | 142 (53.4) | 0.93 (0.65-1.33) | 0.927 | |
| Allelic (T) | 0.96 (0.74-1.26) | 0.790 | |||
| rs7014346 | GG | 99 (44.6) | 119 (44.7) | 1.00 | |
| GA | 97 (43.7) | 115 (43.2) | 1.02 (0.69-1.49) | 0.936 | |
| AA | 26 (11.7) | 32 (12.0) | 0.99 (0.55-1.78) | 0.974 | |
| GA+AA | 123 (55.4) | 147 (55.2) | 1.01 (0.71-1.45) | 0.956 | |
| Allelic (A) | 1.00 (0.77-1.31) | 0.991 | |||
| rs6983267 | TT | 71 (31.7) | 74 (32.6) | 1.00 | |
| GT | 100 (44.6) | 106 (46.7) | 0.99 (0.65-1.53) | 0.974 | |
| GG | 53 (23.7) | 47 (20.7) | 1.20 (0.71-2.00) | 0.498 | |
| GT+GG | 153 (68.3) | 153 (67.4) | 1.06 (0.71-1.57) | 0.794 | |
| Allelic (G) | 1.09 (0.84-1.42) | 0.520 | |||
| rs719725 | AA | 115 (51.6) | 99 (44.0) | 1.00 | |
| CA | 90 (40.4) | 104 (46.2) | 0.71 (0.48-1.06) | 0.091 | |
| CC | 18 (8.1) | 22 (9.8) | 0.70 (0.35-1.40) | 0.316 | |
| CA+CC | 108 (48.5) | 126 (56.0) | 0.71 (0.49-1.04) | 0.075 | |
| Allelic (C) | 0.79 (0.59-1.05) | 0.106 | |||
| rs10795668 | GG | 106 (47.5) | 123 (46.4) | 1.00 | |
| AG | 85 (38.1) | 105 (39.6) | 0.96 (0.65-1.41) | 0.819 | |
| AA | 32 (14.3) | 37 (14.0) | 0.96 (0.56-1.66) | 0.887 | |
| AG+AA | 117 (52.4) | 142 (53.6) | 0.96 (0.67-1.37) | 0.811 | |
| Allelic (A) | 0.97 (0.74-1.27) | 0.829 | |||
| rs3802842 | AA | 68 (32.9) | 62 (30.0) | 1.00 | |
| CA | 94 (45.4) | 112 (54.1) | 0.74 (0.47-1.16) | 0.189 | |
| CC | 45 (21.7) | 33 (15.9) | 1.24 (0.69-2.22) | 0.470 | |
| CA+CC | 139 (67.1) | 145 (70.0) | 0.85 (0.55-1.30) | 0.446 | |
| Allelic (C) | 1.05 (0.80-1.40) | 0.717 | |||
| rs4444235 | TT | 35 (16.3) | 71 (26.7) | 1.00 | |
| CT | 122 (56.7) | 141 (53.0) | 1.82 (1.13-2.92) | 0.014 | |
| CC | 58 (27.0) | 54 (20.3) | 2.27 (1.30-3.94) | 0.004 | |
| CT+CC | 180 (83.7) | 195 (73.3) | 1.94 (1.23-3.06) | 0.004 | |
| Allelic (C) | 1.43 (1.11-1.85) | 0.006 | |||
| rs9929218 | GG | 157 (69.8) | 174 (65.2) | 1.00 | |
| GA | 57 (25.3) | 83 (31.1) | 0.77 (0.52-1.15) | 0.203 | |
| AA | 11 (4.9) | 10 (3.7) | 1.78 (0.49-2.86) | 0.716 | |
| GA+AA | 68 (30.2) | 93 (33.8) | 0.82 (0.56-1.19) | 0.294 | |
| Allelic (A) | 0.89 (0.64-1.23) | 0.484 | |||
| rs10411210 | CC | 152 (68.5) | 181 (68.0) | 1.00 | |
| TC | 65 (29.3) | 74 (27.8) | 1.05 (0.70-1.56) | 0.830 | |
| TT | 5 (2.3) | 11 (4.1) | 0.55 (0.19-1.61) | 0.274 | |
| TC+TT | 70 (31.6) | 85 (31.9) | 0.98 (0.67-1.44) | 0.920 | |
| Allelic (T) | 0.92 (0.66-1.29) | 0.643 | |||
| rs961253 | CC | 179 (79.6) | 230 (86.5) | 1.00 | |
| AC | 46 (20.4) | 36 (13.5) | 1.70 (1.05-2.76) | 0.031 | |
| Allelic (A) | 1.62 (1.02-2.56) | 0.040 |