Table 2. Summary ORs of the XPC polymorphism and cancer risk by ethnicity.
| SNP | Ethnicity | Studies | Case/control | Dominant model |
Recessive model |
Homozygote model |
|||
|---|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | P* | OR (95% CI) | P* | OR (95% CI) | P* | ||||
| XPC Lys939Gln rs2228001 | Overall | 11 | 4,562/6,593 | 1.20 (1.11-1.30) | 0.08 | 1.24 (1.11-1.39) | 0.13 | 1.36 (1.21-1.53) | 0.08 |
| Asian | 7 | 3,376/4,755 | 1.18 (1.02-1.37) | 0.03† | 1.32 (1.15-1.51) | 0.20 | 1.35 (1.08-1.70) | 0.04† | |
| Caucasian | 4 | 1,186/1,838 | 1.09 (0.93-1.27) | 0.87 | 1.10 (0.90-1.34) | 0.22 | 1.17 (0.93-1.46) | 0.71 | |
| Overall | 7 | 1,429/2,724 | 0.95 (0.83-1.08) | 0.45 | 1.09 (0.90-1.33) | 0.24 | 1.04 (0.85-1.28) | 0.24 | |
| XPC intron9 PAT | Asian | 5 | 994/2,186 | 0.99 (0.85-1.16) | 0.55 | 1.05 (0.83-1.32) | 0.10 | 1.04 (0.81-1.34) | 0.10 |
| Caucasian | 2 | 435/538 | 0.83 (0.64-1.07) | 0.27 | 1.20 (0.85-1.69) | 0.83 | 1.04 (0.72-1.51) | 0.54 | |
| XPC Ala499Val rs2228000 | Overall | 6 | 2,496/3,635 | 0.84 (0.76-0.94) | 0.20 | 1.01 (0.86-1.19) | 0.74 | 0.94 (0.79-1.12) | 0.66 |
| Asian | 5 | 2,113/3,185 | 0.84 (0.75-0.94) | 0.12 | 0.98 (0.82-1.16) | 0.91 | 0.90 (0.75-1.09) | 0.81 | |
Test for Heterogeneity; †Random-effects model was used when P value for het erogeneity test <0.05; otherwise, fixed-effect model was used