Table 3. Mutation Analysis of KIT and PDGFRA in Patients before and after imatinib treatment.
Disease status at surgery |
||
---|---|---|
RD (n=10) | PD (n=12) | |
Before imatinib treatment | ||
KIT exon 9 mutation dupc502+c503 | 1 | 3 |
KIT exon11 mutation V559D | 4 | 2 |
KIT exon11 mutation del552-553 | 3 | 0 |
KIT exon11 mutation del553-558 | 1 | 2 |
KIT exon 13 mutation K642E | 0 | 1 |
PDGFRA exon18 mutation D842V | 1 | 3 |
Wild type | 0 | 1 |
After imatinib treatment | ||
Original mutation | 10 | 9 |
Secondary mutation KIT exon 17 Y823D | 0 | 3 |