Table 3. Cox proportional hazard regression model analysis of all the patients.

Variables	Univariate analysis				Multivariate analysis
	Relative risk	95% CI	P				Relative risk	95% CI	P
Gender
Male vs. female	0.827	0.530-1.289	0.402
Age, years
≤60 vs. >60	1.243	0.816-1.771	0.351
Site
Non-cardiac cancer vs. cardiac cancer	1.630	1.045-2.542	0.031
Size
≤4 cm vs. >4 cm	1.489	0.977-2.270	0.064
Lauren
Intestinal	1.606	0.732-3.526	0.237
diffuse	2.582	1.154-5.777	0.021
mixed	1.000		0.018
Differentiation
Well-moderate vs. poor	1.501	1.002-2.247	0.049
Lymphovascular invasion
Absent vs. present	2.370	1.593-3.527	0.000
Depth of invasion
T1+T2 vs. T3+T4	3.935	1.725-8.974	0.001
Lymph node metastasis
N0 vs. N1+N2+N3	2.737	1.425-5.258	0.003				0.280	0.098-0.801	0.020
Distant metastasis
No vs. Yes	5.008	3.235-7.754	0.000				2.701	1.602-4.554	0.001
TNM stage
I+II vs. III+IV	6.215	3.393-11.384	0.000				11.364	3.980-34.012	0.000
LGR5 expression
Negative vs. positive	0.974	0.662-1.431	0.892