Table 2.
Predictors of Achieving Normal Glucose Regulation During DPPOS
| 95% CI | Odds Ratio | P-value | |
|---|---|---|---|
|
| |||
| NGR v. Pre-diabetes (PLB) | 2.25-4.02 | 3.01 | <0.0001 |
| NGR: ILS v. PL | 0.63-1.02 | 0.80 | 0.0678 |
| NGR: MET v. PL | 0.69-1.14 | 0.89 | 0.3481 |
| Pre-diabetes: ILS v. PLB | 0.42-0.82 | 0.59 | 0.0014 |
| Pre-diabetes: MET v. PLB | 0.73-1.32 | 0.98 | 0.9028 |
| Age < 45 | 0.75-1.18 | 0.95 | 0.6243 |
| Age 45-59 | 0.83-1.21 | 1.00 | 0.9968 |
| Age ≥ 60 | reference | - | - |
| Female | 1.00-1.38 | 1.18 | 0.0509 |
| African American | 0.81-1.24 | 1.00 | 0.9697 |
| Hispanic | 0.84-1.30 | 1.04 | 0.7011 |
| Asian | 0.57-1.24 | 0.84 | 0.3794 |
| Native American | 0.67-1.26 | 0.92 | 0.5918 |
| Caucasian | reference | - | - |
| Body mass index | 0.71-0.87 | 0.79 | <0.0001 |
| % Weight Change in DPP | 0.72-0.84 | 0.78 | <0.0001 |
| Insulin resistance | 1.08-1.25 | 1.16 | <0.0001 |
| β-cell function | 1.18-1.39 | 1.28 | <0.0001 |
All results based on a generalized linear mix model for reaching NGR status or not in yearly DPPOS visits.
- Glycemic status and treatment group during DPP
- Demographic and concurrent weight and metabolic information during DPPOS
For categorical predictors, the ORs correspond to the comparison over the reference group; for continuous predictors, the ORs refer to per unit SD in the predictor. For BMI at the beginning of DPPOS, % weight change during DPP,1/[fasting insulin] and CIR, the standard deviation between subjects in DPPOS are 6.83 kg/m2, 7.65%, 35 pmol/l and 0.41 l/pmol respectively.
ILS = intensive lifestyle intervention
MET = metformin
PLB = placebo
NGR = normal glucose regulation
Insulin sensitivity estimated by 1/[fasting insulin]
β-cell function assessed using the Corrected Insulin Response (CIR)