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Protection by Statins in a Murine Model of ALI. Mice were administered either vehicle control or LPS (2 μg/g) and lungs were harvested for histology after 24 hours Inflammatory cell infiltration (small arrows) and interstitial edema (large arrows) were abrogated by intraperitoneal administration of simvastatin (20 mg/kg) 24 hours prior to LPS inhalation, and again at the time of inhalation. (Reproduced with permission from reference 81).
