Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Inhibition of NADPH Oxidase by Statins. The EC NADPH complex comprises two membrane-bound components, p22phox and Nox2, and three cytosolic regulatory subunits, p47phox, p67phox, and Rac1. Statins inhibit complex formation primarily via the inhibition of Rac1 geranylgeranylation, thereby preventing its translocation and subsequent activation at the cell membrane, essential for NADPH oxidase complex assembly and activation.
