Figure 5.

Variability of Statin Lipophilicity. The solubilities of various statins are represented along a spectrum from the most lipophilic to the most hydrophilic. While the more lipophilic statins are associated with a higher propensity for adverse effects (e.g., myositis and myopathy) by virtue of their increased extrahepatic tissue penetration relative to the more hydrophilic statins, they may also be more likely to confer endothelial-protective effects relevant to ALI for this same reason.