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. 2012 Oct-Dec;2(4):443–451. doi: 10.4103/2045-8932.105032

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Copyright: © Pulmonary Circulation

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Cytoprotective effect of exogenous zinc is ZIP14 dependent. LPS induced decreases in labile zinc are associated with increases in capsase-3 activity and upregulation of zinc importer, ZIP14 to restore the loss of labile zinc mediated by LPS. Elevation in labile zinc via ZIP14 inhibits apoptosis by inhibiting caspase-3 activity. siRNA to ZIP14 blocked zinc uptake and abrogated zinc mediated protection against LPS-induced apoptosis.