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Putative mechanisms by which PPARγ ligands attenuate hypoxia-induced HPASMC proliferation. The current schema depicts relationships that exist between TSP-1, Nox4, and ROS generation in hypoxia-induced HPASMC proliferation. Hypoxia enhances Nox4 expression and ROS generation in a TSP-1-mediated manner. Activation of PPARγ with rosiglitazone attenuates hypoxia-induced HPASMC proliferation through inhibitory effects on TSP-1 expression and signaling.
