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Overexpression of the LARGE paralog does not overcome the glycosylation defect in UXS1-deficient (pgsI-208) CHO cells. (A) Immunoblotting of WGA-enriched glycoproteins for functionally modified α-DG (IIH6) and β-DG, or of cell lysates for LARGE and LARGE2, from WT or pgsI-208 cells with or without overexpression of either LARGE or LARGE2. Mr, relative molecular mass. (B) Flow cytometry of the cells for surface staining with IIH6. Dotted line, secondary antibody alone.
