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. 2013 Jan 25;3:1. doi: 10.3389/fonc.2013.00001

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Copyright © He, Liu, Oh and Thiele.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.

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Diagram of MYC functional regions. In the region of the transcriptional activation domain (TAD) the MYC Box II (MBII) binds TRRAP containing complexes of proteins that may also contain GCN5. It is also felt that p-TEFb, Tip60, and a number of other transcriptional regulatory factors can bind to this region. Determinants of which factors bind remain to be resolved. The bHLH region binds E-box containing regions of DNA. MYC dimerizes with other bHLH containing transcription factors via a carboxy-terminal leucine zipper (Zip) region. While MYC recruits HATs such as GCN5 and CBP/p300 which are known to acetylate lysine residue on histone tails, these HATs are also known to acetylate (Ac) MYC which affects its stability by blocking or competing with ubiquitin ligases that target MYC for degradation.