Table 4.
Adverse events
| Treatment | N | Nausea and/or vomiting | Itch | Sedation | Desaturation | Urinary retention | Impairment in hearing | Visual disturbance | Dizziness | Headache | Total |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Placebo | 28 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 2 |
| Morphine, low-dose | 27 | 2 | 4 | 3 | 1 | 0 | 1 | 0 | 2 | 1 | 14 |
| Morphine, high-dose | 28 | 11 | 13 | 11 | 5 | 0 | 2 | 1 | 6 | 1 | 50 |
| Buprenorphine, low-dose | 28 | 14 | 11 | 15 | 3 | 2 | 2 | 1 | 6 | 0 | 54 |
| Buprenorphine, high-dose | 28 | 19 | 18 | 24 | 10 | 2 | 1 | 1 | 8 | 0 | 83 |
Notes: Adverse events registered more than once. The numbers refer to the number of subjects, in each treatment arm, who experienced the symptom.