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Dose Levels and Dose Limiting Toxicities
| Dose level | Oblimersen (mg/kg/d) | Cisplatin (mg/m2) | 5-Fluorouracil (mg/m2/d) | No. Patients | No. Cycles | No. Cycle 1 DLT |
|---|---|---|---|---|---|---|
| 1 | 3 | 100 | 1000 × 5 d | 4 | 14 | 1 |
| 2 | 3 | 75 | 750 × 4 d | 4 | 14 | 0 |
| 3a | 5 | 75 | 750 × 4 d | 3 | 16 | 0 |
| 4 | 7 | 75 | 750 × 4 d | 1 | 2 | 1 |
| 3b | 5 | 75 | 750 × 4 d | 3 | 7 | 0 |
