Table 1.

Values of pD₂ and E_max obtained of concentration-response curves to monoterpenes in isolated rings of rat superior mesenteric artery with functional endothelium pre-contracted with Phe (10 μM)

Monoterpenes	N	pD2	Emax
Rotundifolone (1)	4	5.1 ± 0.2	71.7 ± 6.2
Pulegone epoxide (2)	4	6.3 ± 0.3a,c	55.5 ± 3.0
Carvone epoxide (3)	4	3.4 ± 0.3e	99.8 ± 18.7**,***
(+)-Limonene (4)	4	5.1 ± 0.1	84.2 ± 4.1##
(+)-Limonene epoxide (5)	4	---	34.0 ± 2.0
(+)-Pulegone (6)	4	---	30.3 ± 2.3*

N = Number of experiments; pD₂ – Potency; E_max – Maximum Effect; ^ap < 0.05 vs rotundifolone and (+)-limonene; ^cp < 0.001 carvone epoxide, and ^ep < 0.01 vs rotundifolone and (+)-limonene. *p < 0.05 vs rotundifolone, ***p < 0.001 vs (+)-pulegone and limonene epoxide; **p < 0.01 vs pulegone epoxide, and ^##p < 0.01 vs (+)-pulegone and limonene epoxide.