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. 2013 Jan 25;8(1):e54472. doi: 10.1371/journal.pone.0054472

Figure 5. An intact FXR signalling is required to preserve TLR9 action.

Figure 5

TNBS colitis was induced in FXR+/+ and FXR−/− mice. Mice were administered CpG as described in materials and methods. (A–C) Analysis of Disease activity index (DAI) in FXR+/+ (A) and FXR−/− mice (C). (B–D) Analysis of mucosal damage score in FXR+/+ (B) and FXR−/− mice (D). (E–L) H&E staining of representative paraffin-embedded sections from distal colons after administration of vehicle (control mice), TNBS or TNBS plus CpG in FXR+/+ (panels E–G) and FXR−/− (H–L) mice. Data are mean ± SE of 6animals.*P<0.05 versus naive mice. #P<0.05 versus mice administered TNBS.