Figure 3. Different distribution of bacterial taxa in children with irritable bowel syndrome was correlated with the relative frequency of abdominal pain.⁵⁹ Bacterial taxa (specified in leftmost column) were defined by randomForest and confirmed by feature selection using Boruta. The list is sorted first by Mann-Whitney U score followed by the largest disparity in medians for each group. Taxa represent the lowest taxonomic depth (Genus) that is labeled by the Ribosomal Database Project Classifier. Red rectangles display the HM (high-medium) abdominal pain phenotype. Light blue rectangles display the L0 LO (low-none) abdominal pain phenotype. Boxes represent the first quartile, median and third quartile of the OTU distributions for each pain group. Empty circles represent outliers that are 1.5 greater than the respective interquartile ranges. (A) OTUs with greater abundance in patients with HM vs L0 abdominal pain phenotypes. (B) OTUs with reduced abundance in patients with HM vs L0 abdominal pain phenotypes. Published with permission from Gastroenterology.