Table 2. Crude and adjusted hazard ratios (HR) for the occurrence of hemorrhagic stroke during the two-year follow-up period in the migraine and non-migraine groups.

	Occurrence of hemorrhagic stroke
Variable	Crude HR (95% CI)	‡Adjusted HR (95% CI)	P value for adjusted HR
Migraine (vs. non-Migraine)	2.22* (1.78 – 2.77)	2.13 (1.71 – 2.67)	<0.0001
Age (year)	1.05* (1.04 – 1.06)	1.04 (1.03 – 1.05)	<0.0001
Sex (female vs. male)	0.54* (0.44 – 0.66)	0.62 (0.51 – 0.77)	<0.0001
Hypertension
With antihypertensive medication (vs. no hypertension)	4.18* (3.34 – 5.25)	1.74 (1.34 – 2.26)	<0.0001
Without antihypertensive medication (vs. no hypertension)	3.44* (2.20 – 5.37)	1.74 (1.10 – 2.75)	0.0181
Diabetes (yes vs. no)	3.24* (2.46 – 4.27)	1.52 (1.14 – 2.04)	0.0046
Hyperlipidemia (yes vs. no)	2.04* (1.48 – 2.83)	NS	NS
Coronary heart disease (yes vs. no)	2.82* (2.07 – 3.86)	NS	NS
Chronic rheumatic heart disease (yes vs. no)	5.40* (2.56 – 11.40)	2.62 (1.24 – 5.57)	0.0120
Other heart disease (yes vs. no)	2.91* (2.12 – 4.00)	NS	NS
Use of anticoagulant medication (yes vs. no)	6.50† (2.43 – 17.42)	NS	NS

^*P<0.0001, ^†P<0.001 in the univariate analysis.

^‡The adjusted hazard ratios were derived from the final multiple regression model.

Abbreviations: CI, confidence interval; NS, non-significant.