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. 2013 Jan 25;8(1):e55072. doi: 10.1371/journal.pone.0055072

Figure 2. Small-molecule drug screening identifies fenretinide as promising candidate drug.

Figure 2

A) Fenretinide inhibits reporter gene activity. Rh4-AP2β-LF cells were treated with the small-molecule compound library at a final concentration of 5 µM during 24 hours and luciferase activity (light grey bars) measured as read-out of the screening together with proliferation (dark grey bars) by WST-1 assay. Actual values for the ten top-ranked compounds are shown relative to untreated controls. B) Proliferation and reporter gene activity in Rh4-AP2β-LF compared to SV40-LF cells after fenretinide treatment for 24 hours are shown. Representative values of three independent experiments. Columns, mean; bars, s.d.