Table 1. LOPAC small-molecule compound library screening hit list.
Compound | Ratioa | Description |
Retinoic acid p-hydroxyanilide | 4,51 | Vitamin A acid analog |
(±)-Quinpirole dihydrochloride | 4,29 | Dopamine receptor agonist |
ML 10302 | 4,04 | Serotonin receptor agonist |
Propantheline bromide | 3,95 | Muscarinic acetylcholine receptor antagonist |
N,N,N’,N’-Tetramethylazodicarboxamide | 3,84 | Thiol-oxidizing agent |
Etoposide | 3,8 | Topoisomerase II inhibitor |
L-162,313 | 3,67 | Angiotensin II receptor agonist |
9-cyclopentyladenine | 3,43 | Adenylyl cyclase inhibitor |
R(−)-Isoproterenol (+)-bitartrate | 3,37 | Adrenoceptor agonist |
BRL 50481 | 3,27 | Phosphodiesterase 7 inhibitor |
Ratio = Proliferation rate/Luciferase activity as compared to the non-treated RH4-AP2ß-LF cells (5 µM incubation for 24 hours).