Table 2. Univariate and multivariate survival analysis of clinic-pathologic variables in 406 cases of gastric carcinoma patients.

Variables	n a	Univariate analyses			Multivariate analyses
		HR	(95% CI)	P value	HR	(95% CI)	P value
Age (years)				0.033*			0.028*
<60	230	1.000			1.000
≥60	176	1.367	1.025–1.882		1.396	1.037–1.879
Gender				0.376
Male	276	1.000
Female	130	1.148	0.847–1.556
Tumor size				<0.001*			<0.001*
<2.5 cm	51	1.000			1.000
2.5–5 cm	210	4.002	1.748–9.163		2.441	1.052–5.663
>5 cm	145	6.483	2.828–14.866		3.767	1.617–8.775
histological grade				0.012*			0.007*
G1/G2	156	1.000			1.000
G3	250	1.488	1.093–2.027		1.553	1.125–2.143
Tumor location				0.084
Proximal	236	1.000
Distant	153	0.538	0.382–0.757
Total	17	1.806	0.972–3.354
Lymphovascular invasion				<0.001*			<0.001*
No	367	1.000			1.000
Yes	39	2.956	1.995–4.379		2.267	1.511–3.400
Tumor invasion				<0.001*			0.004*
T1/T2/T3	146	1.000			1.000
T4a/T4b	260	2.561	1.810–3.624		1.701	1.190–2.432
Nodal status				<0.001*			0.001*
N0	115	1.000			1.000
N+	291	2.838	1.897–4.245		1.993	1.323–3.002
Metastasis status				<0.001*			<0.001*
M0	354	1.000			1.000
M1	52	5.151	3.677–7.215		3.527	2.492–4.991
TCEAL7				<0.001*			0.009*
High	230	1.000			1.000
Low	176	1.950	1.227–2.760		1.658	1.116–2.108

HR, hazard ratio; CI, confidence interval;

^aNumbers of cases in each group;

^*Statistically significant (P<0.05).